克罗米酚对男性偏高促性腺素性功能减退症有效

纽约（路透社健康旧版）1年底四日报道：据登载在12年底出旧版的《生育与子代》刊物的一项通报指出克罗米萘对部分高促持续性腺伦持续性机能减退的男持续性高血压稳固。来自伯明翰密苏里医学院的该通报的第一创作者Scott J. Whitten博士在接受路透通讯社采访时却说：“原发持续性或获得持续性HH高血压在接受侵害持续性非常大和极为昂贵的用药（例如注射促持续性腺激伦类）前展开4个年底的克罗米萘试验持续性用药是稳固的。”Whitten博士和同僚研究了克罗米萘对10名HH男持续性高血压（HH是造成了男持续性子代的罕有因伦）是否适当。通报称克罗米萘用药1年后，4名西蒙(德川氏)症高血压中只有一名高血压的精子含量增加而全脑下垂体机能减退症高血压的精子忽视症状均没有得到优化。也就是却说，该通报指出3名成年发病的原发持续性HH男持续性高血压经过3个年底克罗米萘的用药精子含量有了明显增加。迄今该组高血压有数两名恢复了生育能力。Whitten博士却说：“除非对克罗米萘用药没有反应会，我们才会因为过敏反应停止对高血压使用该药物。”先前创作者总结却说：“因为条件局限，对HH高血压促持续性腺激伦类药物和克罗米萘的随机研究难以展开，然而利用多系列的完全符合选择标准化对高血压展开标准可能鼓励进一步验证克罗米萘恢复男持续性高生育能力的适当持续性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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编辑： 张靖